CURIO SEEKER
High-resolution spatial mapping
Curio Seeker enables whole-transcriptome, spatial mapping of fresh frozen tissue at industry-leading resolution and plugs directly into existing sequencing workflows.
A spatially indexed surface, the Curio Seeker tile preserves spatial information of the tissue transcriptome by capturing RNA on an indexed surface composed of a monolayer of tightly packed, 10 μm beads.
Once captured, the RNA undergoes reverse transcription, library preparation, and sequencing. The resulting data can be reconstructed into a continuous, whole-transcriptome map of your region of interest.
High-resolution
expression maps
Sequencing data is reconstructed bioinformatically into a continuous, whole-transcriptome map of your region of interest using the Curio Seeker bioinformatics pipeline.
Expression pattern of the top ten spatially differential genes from a section of murine hippocampus.
(click to enlarge)
Reveal spatial organization
of cell clusters
Standard HTML output from the Curio Seeker Pipeline includes unbiased UMAP clustering (left) and a spatial map of the localization of the identified clusters (right). These plots enable the end user to easily determine if the data is biologically meaningful and of high quality. (click to enlarge)
Annotate cell clusters using
single-cell data
Use cutting-edge, open source, bioinformatic pipelines such as RCTD to easily phenotype your cells with existing or concurrent single-cell data sets. (click to enlarge)
Amenable to a wide variety of tissue types
Generate high-resolution transcriptomics information across a wide range of tissue types using the same protocol.
Mouse Liver (click to enlarge)
Mouse Spleen (click to enlarge)
Mouse Kidney (click to enlarge)
Simplified workflow designed to integrate into standard molecular biology lab setup
Once captured, the RNA undergoes reverse transcription, library preparation, and sequencing.
Whole-transcriptome spatial biology made easy
Curio Seeker – Technology overview
Customer perspectives – Integrating into a core lab setting
Curious?
CURIO SEEKER
Product Sheets &
Sample Pipeline Report
Access an overview of the Curio Seeker technology
