Curio Seeker enables whole-transcriptome, spatial mapping of fresh frozen tissue at industry-leading resolution and plugs directly into existing sequencing workflows.
A spatially indexed surface, the Curio Seeker tile preserves spatial information of the tissue transcriptome by capturing RNA on an indexed surface composed of a monolayer of tightly packed, 10 μm beads.
Once captured, the RNA undergoes reverse transcription, library preparation, and sequencing. The resulting data can be reconstructed into a continuous, whole-transcriptome map of your region of interest.
Sequencing data is reconstructed bioinformatically into a continuous, whole-transcriptome map of your region of interest using the Curio Seeker bioinformatics pipeline.
Standard HTML output from the Curio Seeker Pipeline includes unbiased UMAP clustering (left) and a spatial map of the localization of the identified clusters (right). These plots enable the end user to easily determine if the data is biologically meaningful and of high quality. (click to enlarge)
Once captured, the RNA undergoes reverse transcription, library preparation, and sequencing.
Whole-transcriptome spatial biology made easy
Curio Seeker – Technology overview
Customer perspectives – Integrating into a core lab setting
Access an overview of the Curio Seeker technology
See the kind of data you can uncover with Curio Seeker