Slide-seq: a platform for understanding cellular circuits in tissue

The precise spatial localization of molecular signals within tissues richly informs the mechanisms of tissue formation and function. Here we introduce Slide-seq, a technology which enables transcriptome-wide measurements with near single-cell spatial resolution. We’ll describe recent experimental and computational advances to enable Slide-seq in biological contexts where high detection sensitivity is important. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics.

Play Video